2025 was a landmark year for ketogenic diet research. Several significant trials and meta-analyses added substantial evidence to the clinical picture. Here is what the science now shows.
A 2025 multi-centre UK trial involving 600 type 2 diabetics showed that a very low-carbohydrate diet produced diabetes remission (HbA1c under 48 mmol/mol without medication) in 51% of participants at 24 months — the highest remission rate of any dietary intervention studied to date.
A 2025 meta-analysis confirmed keto’s superiority for triglyceride reduction and HDL elevation but found heterogeneous LDL responses requiring individual monitoring. The overall cardiovascular risk assessment requires a comprehensive lipid panel, not just total cholesterol.
Three new studies in 2025 strengthened the connection between ketogenic metabolism and reduced risk of mild cognitive impairment. A ketogenic diet in midlife was associated with 24% reduced risk of Alzheimer’s diagnosis in a 15-year prospective cohort study.
Research confirmed that strategic inclusion of keto-compatible prebiotics (psyllium, inulin from leeks and asparagus) maintains gut microbiome diversity on keto. Explore our fibre-rich keto salads and prebiotic-rich keto mains.
2025 research substantially strengthened keto’s evidence base. The science is increasingly clear: a well-formulated ketogenic diet is one of the most evidence-backed interventions in nutritional medicine.