Keto and the Immune System: How Low-Carb Eating Affects Immunity
The immune system is deeply intertwined with metabolism. The ketogenic diet, by shifting the body’s metabolic state, has meaningful effects on immune function — most of them positive.
Reducing Inflammatory Signalling
BHB (beta-hydroxybutyrate) inhibits the NLRP3 inflammasome, reducing pro-inflammatory cytokines. Chronic low-grade inflammation suppresses immune function — reducing it improves immune responsiveness.
Blood Sugar and Immunity
High blood sugar impairs white blood cell function. People with diabetes are significantly more susceptible to infections. By normalising blood glucose, keto supports healthy immune cell activity.
Fasting and Autophagy
The fasting periods common in keto practice (intermittent fasting, extended fasting) trigger autophagy — cellular “self-cleaning” — which removes damaged proteins and pathogens, strengthening immunity.
Micronutrient Considerations
Ensure adequate vitamin C (from leafy greens and peppers), zinc (from meat and seeds), and vitamin D (from fatty fish and sun exposure) on keto. These are critical immune nutrients.