Keto and Epilepsy: The Original Therapeutic Use of the Ketogenic Diet
Most people associate keto with weight loss, but the diet was originally developed in the 1920s as a medical treatment for epilepsy — and it remains a clinically supported therapy today.
The Origin Story
In 1921, Dr Russell Wilder at the Mayo Clinic formalised the ketogenic diet as a treatment for epilepsy. He observed that fasting reduced seizures and hypothesised that a high-fat, low-carb diet could mimic fasting’s effects while allowing normal nutrition.
How Keto Reduces Seizures
The precise mechanism is still not fully understood, but ketones appear to stabilise neuronal membrane potentials, reduce glutamate (excitatory) activity, and increase GABA (inhibitory) activity in the brain.
Clinical Effectiveness
Approximately 50% of children with drug-resistant epilepsy achieve a 50%+ reduction in seizure frequency on the ketogenic diet. Around 10–15% become seizure-free.
The Diet Must Be Medically Supervised for Epilepsy
Therapeutic ketogenic diets for epilepsy are stricter than standard keto (often 4:1 fat-to-protein+carb ratio) and must be managed by a ketogenic diet team at a specialist centre.