Autophagy and Keto: How Fasting Triggers Cellular Self-Cleaning
Autophagy — from the Greek “self-eating” — is the cellular process by which damaged proteins, dysfunctional organelles, and pathogens are broken down and recycled. It is one of the most exciting areas of longevity research and is significantly triggered by keto and fasting.
Discovering Autophagy
Japanese cell biologist Yoshinori Ohsumi won the 2016 Nobel Prize in Physiology or Medicine for his discoveries about autophagy mechanisms, bringing this cellular process to global scientific attention.
How Keto Triggers Autophagy
Low insulin levels and low mTOR signalling — both products of carbohydrate restriction — are the primary triggers for autophagy. Combined with fasting periods, keto creates an ideal environment for maximal autophagy.
What Autophagy Does
Removes damaged cellular components before they accumulate. Reduces cancer risk by eliminating pre-cancerous proteins. Improves mitochondrial function. Supports immune system health. Associated with extended lifespan in animal models.
Maximising Autophagy
Combine keto with 16–24 hour fasting periods for maximum autophagy. Avoid eating within 2–3 hours of sleep. Break fasts with our keto beverages and restart with meals from our keto breakfast collection.